Spontaneous gallbladder pathology in baboons


  • This research was funded in part by National Institutes of Health/National Center for Research Resources (NIH/NCRR) Grant P51 RR013986 to the Southwest National Primate Research Center. Non-human primates were housed in facilities constructed with support from Research Facilities Improvement Program Grant C06 RR016228 from the NIH/NCRR. This study was supported by the Southwest National Primate Research Center summer student internship program (P51 RR013986).

Edward J. Dick Jr, DVM, DACVP,
Southwest Foundation for Biomedical Research, PO Box 760549
San Antonio, TX 78245-0549, USA.
Tel.: +1-210-258-9894;
fax: +1-210-670-3305;
e-mail: edick@sfbr.org


Background  Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans.

Methods  A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP.

Results  Ninety-seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%).

Conclusion  Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans.