Analysis of the bone metabolism by quantitative computer tomography and clinical chemistry in a primate model (Callithrix jacchus)

Authors


Jana Grohmann, Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, An den Tierkliniken 1, 04103 Leipzig, Germany.
Tel.: +49 341 9738111;
fax: +49 341 9738119;
e-mail: jana.grohmann@vetmed.uni-leipzig.de
Almuth Einspanier, Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, An den Tierkliniken 1, 04103 Leipzig, Germany.
Tel.: +49 341 9738102;
fax: +49 341 9738119;
e-mail: einspanier@vetmed.uni-leipzig.de

Abstract

Background  Common marmosets are widely used as experimental primates; however, little is still known about their bone physiology. Therefore, the aim of our study was to analyse body weight, age and bone-specific blood parameters in relation to morphological bone parameters.

Methods  Fifty-eight common marmosets were analysed for blood calcium (Ca), inorganic phosphor (Pi), alkaline phosphatase (AP) and 17-β-estradiol (E2). The examination of bone parameters was undertaken in the lumbar spine by computer tomography.

Results  There was a correlation between bone mineral density (BMD) and body weight, trabecular area ratio and polar moment as well as between BMD and AP or Ca (only males), whereas there were no correlations between BMD and age, Pi or E2 in all analysed genders.

Conclusions  Our data support the assumption that the common marmoset is a reliable primate model to study changes in bone metabolism because of the similarity of our results to humans.

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