Oral candidiasis established in the sialoadenectomised rat


Críspían Scully, Centre for the Study of Oral Disease, University of Bristol Dental Hospital and School. Lower Maudlin Street, Bristol BS1 2LY, England


Xerostomia provoked in rats by surgical removal of the major salivary glands favoured the development of oral candidiasis. After 32 weeks of inoculation, 20% of normal and 70% of xerostomic rats showed candidal infection on the tongue but only in xerostomic rats did candidiasis affect the pharyngeal aspect of the tongue.