Role of thermal trauma in experimental oral mucosal Candida infections in rats

  1. John F. O'Grady,
  2. Peter C. Reade*

Article first published online: 28 APR 2006

DOI: 10.1111/j.1600-0714.1993.tb01044.x

Issue

Journal of Oral Pathology & Medicine

Journal of Oral Pathology & Medicine

Volume 22, Issue 3, pages 132–137, March 1993

Additional Information

How to Cite

O'Grady, J. F. and Reade, P. C. (1993), Role of thermal trauma in experimental oral mucosal Candida infections in rats. Journal of Oral Pathology & Medicine, 22: 132–137. doi: 10.1111/j.1600-0714.1993.tb01044.x

Author Information

  1. Section of Oral Medicine and Oral Surgery, School of Dental Science, University of Melbourne, Australia

*P. C. Reade, School of Dental Science, University of Melbourne, 711 Elizabeth Street, Melbourne, Victoria, 3000, Australia.

Publication History

  1. Issue published online: 28 APR 2006
  2. Article first published online: 28 APR 2006
  3. Accepted for publication September 30, 1992

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Keywords:

  • Candida albicans;
  • candidosis;
  • trauma

A model of candidosis in experimental rats was used to study the role of trauma in the aetiology of oral mucosal infections caused by Candida albicans. Standardised thermal trauma was delivered to the dorsum of the tongue of Sprague-Dawley rats and experimental candidosis was induced. Histologically. the site of trauma was invaded by hyphae earlier and more extensively than in control animals, leading to the conclusion that trauma facilitated the establishment of the C. alhicana infections.

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