Elevated serum levels of the apoptosis related molecules TNF-α, Fas/Apo-1 and Bcl-2 in oral lichen planus
Article first published online: 13 JUL 2004
Journal of Oral Pathology & Medicine
Volume 33, Issue 7, pages 386–390, August 2004
How to Cite
Sklavounou-Andrikopoulou, A., Chrysomali, E., Iakovou, M., Garinis, G. A. and Karameris, A. (2004), Elevated serum levels of the apoptosis related molecules TNF-α, Fas/Apo-1 and Bcl-2 in oral lichen planus. Journal of Oral Pathology & Medicine, 33: 386–390. doi: 10.1111/j.1600-0714.2004.00221.x
- Issue published online: 13 JUL 2004
- Article first published online: 13 JUL 2004
- Accepted for publication December 23, 2003
- lichen planus;
- serum levels;
- tumor necrosis factor-a
Background: The serum circulatory levels of apoptosis related molecules measured in patients with oral lichen planus (OLP) and healthy individuals in order to investigate possible alterations associated with the clinical forms of OLP.
Methods: Serum levels of tumor necrosis factor (TNF)-α, soluble Fas (sFas) and Bcl-2 studied by enzyme-linked immunosorbent assay in whole blood samples in 13 OLP reticular, 13 OLP atrophic-erosive form patients and 26 healthy subjects.
Results: Significantly elevated levels of TNF-α and sFas detected in OLP patients as compared with controls. Serum concentrations of Bcl-2 although increased in 17/26 patients, they were not statistically significant. Reticular OLP exhibited slightly elevated TNF-α and significantly elevated Bcl-2 serum levels, compared with erosive OLP.
Conclusions: These data suggest that a putative dysfunction in the Fas/FasL mediated apoptosis might be involved in the OLP pathogenesis. A downregulation of Bcl-2 serum levels in the atrophic-erosive OLP may be associated with promotion of the disease activity.