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Assessment of SS-A and SS-B in parotid saliva of patients with Sjögren's syndrome
Article first published online: 7 MAR 2005
DOI: 10.1111/j.1600-0714.2004.00301.x
Additional Information
How to Cite
Hammi, A. R., Al-Hashimi, I. H., Nunn, M. E. and Zipp, M. (2005), Assessment of SS-A and SS-B in parotid saliva of patients with Sjögren's syndrome. Journal of Oral Pathology & Medicine, 34: 198–203. doi: 10.1111/j.1600-0714.2004.00301.x
Publication History
- Issue published online: 7 MAR 2005
- Article first published online: 7 MAR 2005
- Accepted for publication October 18, 2004
- Abstract
- Article
- References
- Cited By
Keywords:
- autoantibodies;
- diagnosis;
- saliva;
- Sjögren's syndrome;
- SS-A;
- SS-B
Background: The purpose of this study was to compare the sensitivity of parotid saliva to that of serum in detecting anti-SSA/Ro and anti-SSB/La autoantibodies in patients with Sjögren's syndrome.
Methods: Forty patients and 20 controls participated in the study; all patients met the 1993 European Community criteria for the diagnosis of Sjögren's syndrome. Healthy controls were age- and sex-matched individuals with no signs or symptoms of Sjögren's syndrome. Serum and saliva samples were evaluated using AffiniTech SSA/Ro and SSB/La antibodies kits (AffiniTech, Ltd. Bentonville, AR, USA). The results were also compared with serological status of SS-A and SS-B as reported by an independent clinical laboratory.
Results: Serum was significantly more sensitive than saliva in detecting SSA/Ro and SSB/La antibodies (P = 0.001). There was high agreement between the results with the AffiniTech kits and the independent laboratory (kappa = 0.80; P < 0.001). However, there was poor agreement between saliva and serum results (kappa = 0.174; P = 0.168).
Conclusions: The overall results appear to support that serum analysis is effective method for evaluating the presence of SS-A and SS-B autoantibodies.