Increased survivin expression in high-grade oral squamous cell carcinoma: a study in Indian tobacco chewers
Article first published online: 9 OCT 2006
Journal of Oral Pathology & Medicine
Volume 35, Issue 10, pages 595–601, November 2006
How to Cite
Jane, C., Nerurkar, A. V., Shirsat, N. V., Deshpande, R. B., Amrapurkar, A. D. and Karjodkar, F. R. (2006), Increased survivin expression in high-grade oral squamous cell carcinoma: a study in Indian tobacco chewers. Journal of Oral Pathology & Medicine, 35: 595–601. doi: 10.1111/j.1600-0714.2006.00473.x
- Issue published online: 9 OCT 2006
- Article first published online: 9 OCT 2006
- Accepted for publication May 3, 2006
- oral cancer
Background: Oral cancer is one of the five leading sites of cancer in the Indian population. In the present study we analyzed the expression of apoptosis regulating genes, viz. survivin, Bcl-2, Bax and p53 in precancerous and cancerous lesions of the buccal mucosa of Indian tobacco chewers.
Method: Paraffin-embedded tissue samples from 38 patients with primary oral squamous cell carcinoma (OSCC) and 17 patients with leukoplakia were used. The expression of survivin, Bcl-2, Bax, and p53 was evaluated using immunohistochemical staining method.
Results: Thirty-six percent OSCC were found to be positive for nuclear p53 staining while none of the precancerous lesions showed p53 positivity. Survivin, Bcl-2 and Bax expression was found to increase with increased grade of malignancy. Increase in survivin expression was statistically most significant (P < 0.001).
Conclusion: Increased expression of anti-apoptotic survivin in high-grade tumors suggests that survivin is likely to contribute significantly to apoptosis resistance in response to therapy.