Based on a thesis submitted to the post-graduate faculty, Eastman Dental Institute for Oral Health Care Sciences, University of London, in partial fulfilment of the requirements for the MSc degree.
Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features*
Article first published online: 26 JUL 2007
Journal of Oral Pathology & Medicine
Volume 37, Issue 2, pages 107–121, February 2008
How to Cite
Arduino, P. G. and Porter, S. R. (2008), Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features. Journal of Oral Pathology & Medicine, 37: 107–121. doi: 10.1111/j.1600-0714.2007.00586.x
- Issue published online: 26 JUL 2007
- Article first published online: 26 JUL 2007
- Accepted for publication April 15, 2007
- clinical features;
- Herpes Simplex Virus Type 1;
- viral aspects
Herpes Simplex Virus Type 1 (HSV-1) is a nuclear replicating enveloped virus, usually acquired through direct contact with infected lesions or body fluids (typically saliva). The prevalence of HSV-1 infection increases progressively from childhood, the seroprevalence being inversely related to socioeconomic background. Primary HSV-1 infections in children are either asymptomatic or following an incubation period of about 1 week gives rise to mucocutaneous vesicular eruptions. Herpetic gingivostomatitis typically affects the tongue, lips, gingival, buccal mucosa and the hard and soft palate. Most primary oro-facial HSV infection is caused by HSV-1, infection by HSV-2 is increasingly common. Recurrent infections, which occur at variable intervals, typically give rise to vesiculo-ulcerative lesions at mucocutaneous junctions particularly the lips (herpes labialis). Recurrent HSV-1 infection within the mouth is uncommon in otherwise healthy patients, although in immunocompromised patients, recurrent infection can be more extensive and/or aggressive. The diagnosis of common herpetic infection can usually be based upon the clinical history and presenting features. Confirmatory laboratory diagnosis is, however, required when patients are, or may be, immunocompromised.