Expression of IFN-γ before and after treatment of oral lichen planus with 0.1% fluocinolone acetonide in orabase

  1. Pornpan Youngnak-Piboonratanakit1,
  2. Kittipong Dhanuthai2,
  3. Kobkan Thongprasom1,
  4. Pimporn Luckprom1,
  5. Wilairat Sarideechaigul3,
  6. Lakana Luangjarmekorn1,
  7. Miyuki Azuma4

Article first published online: 15 JUL 2009

DOI: 10.1111/j.1600-0714.2009.00805.x

Issue

Journal of Oral Pathology & Medicine

Journal of Oral Pathology & Medicine

Volume 38, Issue 9, pages 689–694, October 2009

Additional Information

How to Cite

Youngnak-Piboonratanakit, P., Dhanuthai, K., Thongprasom, K., Luckprom, P., Sarideechaigul, W., Luangjarmekorn, L. and Azuma, M. (2009), Expression of IFN-γ before and after treatment of oral lichen planus with 0.1% fluocinolone acetonide in orabase. Journal of Oral Pathology & Medicine, 38: 689–694. doi: 10.1111/j.1600-0714.2009.00805.x

Author Information

  1. 1

    Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand

  2. 2

    Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand

  3. 3

    Department of Oral Medicine, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand

  4. 4

    Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

*Pornpan Youngnak-Piboonratanakit, DDS, MS (Oral Medicine), PhD (Oral Surgery), Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand. Tel: +6622188942, Fax: +6622188941, E-mail: pornpan.p@chula.ac.th

Publication History

  1. Issue published online: 1 OCT 2009
  2. Article first published online: 15 JUL 2009
  3. Accepted for publication May 27, 2009

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Keywords:

  • fluocinolone acetonide;
  • interferon-γ;
  • oral lichen planus

Background:  Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease in which T-cell-mediated immune responses are implicated in the pathogenesis. The purpose of this study was to investigate the effect of 0.1% fluocinolone acetonide in orabase (FAO) on the in situ expression of IFN-γ in patients with OLP.

Methods:  Twenty OLP patients were enrolled in this study. Biopsy specimens and serum samples were obtained before and 1-month after the treatment with 0.1% FAO. In situ expression and serum levels of IFN-γ were determined using immunohistochemistry and ELISA, respectively.

Results:  The number of IFN-γ-positive mononuclear cells in OLP lesions before the treatment was significantly higher as compared with that after the treatment. Similarly, the mean number of total mononuclear cells was clearly decreased after the treatment. However, the serum levels of IFN-γ were not detectable.

Conclusions:  Our results suggest that IFN-γ expression in OLP tissue may involve in the immunopathogenesis and the treatment with 0.1% FAO had an immunomodulating effect on the decrease of IFN-γ.

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