Cancer stem cell immunophenotypes in oral squamous cell carcinoma
Article first published online: 15 NOV 2010
© 2010 John Wiley & Sons A/S
Journal of Oral Pathology & Medicine
Volume 40, Issue 2, pages 135–142, February 2011
How to Cite
Oliveira, L. R., Oliveira-Costa, J. P., Araujo, I. M., Soave, D. F., Zanetti, J. S., Soares, F. A., Zucoloto, S. and Ribeiro-Silva, A. (2011), Cancer stem cell immunophenotypes in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine, 40: 135–142. doi: 10.1111/j.1600-0714.2010.00967.x
- Issue published online: 28 JAN 2011
- Article first published online: 15 NOV 2010
- Accepted for publication September 3, 2010
- cancer stem cell;
- oral cancer
J Oral Pathol Med (2011) 40: 135–142
Background: The presence of cancer stem cell (CSC) antigens can be evidenced in some human tumors by phenotypic analysis through immunostaining. This study aims to identify a putative CSC immunophenotype in oral squamous cell carcinoma (OSCC) and determine its influence on prognosis.
Methods: The following data were retrieved from 157 patents: age, gender, primary anatomic site, smoking and alcohol intake, recurrence, metastases, histologic classification, treatment, disease-free survival (DFS), and overall survival (OS). An immunohistochemical study for CD44 and CD24 was performed in a tissue microarray of 157 paraffin blocks of OSCCs.
Results: In univariate analysis, the immunostaining pattern showed significant influences in relation to OS for alcohol intake and treatment, as well as for the CD44+ and CD44−/CD24− immunophenotypes. The multivariate test confirmed these associations.
Conclusions: Based on our results, the CD44 immunostaining and the absence of immunoexpression of these two investigated markers can be used in combination with other clinicopathologic information to improve the assessment of prognosis in OSCC.