Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma
Article first published online: 24 DEC 2010
© 2010 John Wiley & Sons A/S
Journal of Oral Pathology & Medicine
Volume 40, Issue 5, pages 385–389, May 2011
How to Cite
Ryott, M., Marklund, L., Wangsa, D., Elmberger, G. and Munck-Wikland, E. (2011), Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma. Journal of Oral Pathology & Medicine, 40: 385–389. doi: 10.1111/j.1600-0714.2010.00992.x
- Issue published online: 12 APR 2011
- Article first published online: 24 DEC 2010
- Accepted for publication November 17, 2010
- head and neck cancer;
- squamous cell carcinoma
J Oral Pathol Med (2010) 40: 385–389
Background: Cyclooxygenase-2 expression is associated with unfavorable outcome in various cancers, and evidence is accumulating that carcinogenesis possibly evolves from intracellular changes in response to induction of this enzyme. Today selective cyclooxygenase-2 inhibitors are being studied and used as complement in cancer treatment. This study examined the prognostic value of cyclooxygenase-2 expression in oral tongue squamous cell carcinoma (OTSCC).
Methods: Expression of cyclooxygenase-2 was determined in biopsies from 76 stage matched patients with OTSCC by immunohistochemistry between January 2000 and December 2004 in Stockholm, Sweden. Additionally, twelve samples taken after pre-operative radiotherapy were investigated.
Results: All OTSCC specimen expressed cyclooxygenase-2 by immunostaining. The cyclooxygenase-2 staining intensity increased significantly with more advanced stage (P = 0.020). Fifty percent of the surgical specimen showed a decrease in immunostaining post-radiation (P = 0.031). No association was found with survival.
Conclusion: Cyclooxygenase-2 expression has limited prognostic value in OTSCC.