Get access

Current trends in miRNAs and their relationship with oral squamous cell carcinoma

Authors

  • Mario Pérez-Sayáns,

    1. Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela, Spain
    2. Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain
    Search for more papers by this author
  • Gayoso-Diz Pilar,

    1. Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain
    2. Clinical Epidemiology and Biostatistics Unit, Hospital Clínico Universitario de Santiago de Compostela, A Choupana, Santiago de Compostela, Spain
    Search for more papers by this author
  • Francisco Barros-Angueira,

    1. Molecular Medicine Unit, Fundación Pública Galega de Medicina Xenómica, Edificio de Consultas planta -2, Hospital Clinico Universitario, Santiago de Compostela, Spain
    Search for more papers by this author
  • José Manuel Suárez-Peñaranda,

    1. Pathological Anatomy Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Search for more papers by this author
  • Alexia Conde Fernández,

    1. Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela, Spain
    Search for more papers by this author
  • José Manuel Gándara-Rey,

    1. Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela, Spain
    Search for more papers by this author
  • Abel García-García

    1. Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela, Spain
    2. Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain
    Search for more papers by this author

Mario Pérez-Sayáns, PhD, DDS, Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela C.P. 15782, Spain. Tel: +0034626233504, Fax: +0034986295424, E-mail: perezsayans@gmail.com

Abstract

J Oral Pathol Med (2012) 41: 433–443

A micro RNA (miRNA) is a single-stranded endogenous, non-coding RNA, with length ranging between 18 and 24 nucleotides and the ability of regulating the expression of other genes on a post-transcriptional level by means of various processes, degradation or repression of target mRNA. miRNAs play a crucial role in regulating fundamental processes such as cell cycle, differentiation and apoptosis; thus, their deregulation can affect normal cell growth and development, and even participate in carcinogenesis. The goals of this paper are: to outline the formation and functions of miRNAs; to determine their role in oral squamous cell carcinoma; to analyze the different miRNAs described and their roles as oncogenes or tumor suppressor genes, depending on their overexpression or subexpression; to describe the different polymorphisms and epigenetic alterations identified; and to determine their role in multidrug resistance.

Ancillary