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The role of carbonic anhydrase IX in hypoxia control in OSCC

Authors

  • Mario Pérez-Sayáns,

    1. Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain
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  • Claudiu T. Supuran,

    1. Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino (Firenze), Italy
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  • Silvia Pastorekova,

    1. Institute of Virology, Slovak Academy of Sciences
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  • José Manuel Suárez-Peñaranda,

    1. Servicio de Anatomia Patológica, Hospital Clinico Universitario de Santiago, Choupana s/n Santiago de Compostela, Spain
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  • Gayoso-Diz Pilar,

    1. Clinical Epidemiology and Biostatistics Unit, Hospital Clínico Universitario de Santiago de Compostela, Spain
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  • Francisco Barros-Angueira,

    1. Unidad de Medicina Molecular – Fundación Pública Galega de Medicina Xenómica, Edificio de Consultas planta, Hospital Clinico Universitario C.P. Santiago de Compostela, Spain
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  • José Manuel Gándara-Rey,

    1. Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela, Spain
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  • Abel García-García

    1. Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain
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Mario Pérez-Sayáns, Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Entrerríos s/n, Santiago de Compostela, C.P. 15782 Spain. Tel: +0034626233504, Fax: +0034986295424, E-mail: perezsayans@gmail.com

Abstract

Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved in the promotion of genetic instability, the invasive capacity of tumor cells, metastasis, and a worsening of the clinical evolution. Endogenous hypoxia markers are controlled by hypoxia-related genes, formed by HIF-1, which is related to several target genes that involve the energy metabolism, angiogenesis, and transmembrane carbonic anhydrases (CAs), mainly CA-IX that is one of the tumor-related carbonic anhydrases. The goal of this paper is to establish the role of CA-IX as a hypoxia marker in OSCC, while analyzing its expression in this type of tumors and its relationship with several clinical and pathological parameters and prognosis, evaluating its relationship with angiogenesis, other hypoxia markers, and clarifying its role in chemotherapy and radiotherapy resistance.

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