In the past decade, follow-up studies on fiber-reinforced composite fixed partial dentures (FRC FPDs) have been described. Combining the results of these studies to draw conclusions about the effectiveness of FRC FPDs is challenging. The objective of this systematic review was to obtain survival rates of FRC FPDs and to explore the relationships between reported survival rates and risk factors. In a literature-selection procedure on the clinical performance of FRC FPDs, 15 studies, reporting on 13 sets of patients, were analyzed. The Kaplan–Meier estimate of the overall survival, based on the data from all sets of patients (n = 435) was 73.4% (69.4–77.4%) at 4.5 yr. Converted survival rates at 2 yr of follow-up showed substantial heterogeneity between studies. It was not possible to build a reliable regression model that indicated risk factors. The technical problems most commonly described were fracture of the FPD and delamination of the veneering composite.