Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patients

  1. Tiit Nikopensius1,2,
  2. Stefanie Birnbaum3,
  3. Kerstin U. Ludwig3,4,
  4. Triin Jagomägi5,
  5. Mare Saag5,
  6. Stefan Herms3,4,
  7. Michael Knapp6,
  8. Per Hoffmann3,4,
  9. Markus M. Nöthen3,4,
  10. Andres Metspalu1,2,7,
  11. Elisabeth Mangold3

Article first published online: 11 MAY 2010

DOI: 10.1111/j.1600-0722.2010.00741.x

Issue

European Journal of Oral Sciences

European Journal of Oral Sciences

Volume 118, Issue 3, pages 317–319, June 2010

Additional Information

How to Cite

Nikopensius, T., Birnbaum, S., Ludwig, K. U., Jagomägi, T., Saag, M., Herms, S., Knapp, M., Hoffmann, P., Nöthen, M. M., Metspalu, A. and Mangold, E. (2010), Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patients. European Journal of Oral Sciences, 118: 317–319. doi: 10.1111/j.1600-0722.2010.00741.x

Author Information

  1. 1

    Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

  2. 2

    Estonian Biocentre, Tartu, Estonia

  3. 3

    Institute of Human Genetics, University of Bonn, Bonn, Germany

  4. 4

    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany

  5. 5

    Department of Stomatology, Faculty of Medicine, University of Tartu, Tartu, Estonia

  6. 6

    Institute of Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, Germany

  7. 7

    Estonian Genome Center, University of Tartu, Tartu, Estonia

*T. Nikopensius, Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia Telefax: +372–7–420286 E-mail: tiitn@ebc.ee.

Publication History

  1. Issue published online: 11 MAY 2010
  2. Article first published online: 11 MAY 2010
  3. Accepted for publication March 2010

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (94K)

Keywords:

  • case–control association study;
  • genotyping;
  • non-syndromic cleft lip with or without cleft palate;
  • single nucleotide polymorphism (SNP)

Nikopensius T, Birnbaum S, Ludwig KU, Jagomägi T, Saag M, Herms S, Knapp M, Hoffmann P, Nöthen MM, Metspalu A, Mangold E. Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patients. Eur J Oral Sci 2010; 118: 317–319. © 2010 The Authors. Journal compilation © 2010 Eur J Oral Sci

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common birth defects and has a multifactorial etiology that includes both genetic and environmental factors. Recently, two novel susceptibility loci and three suggestive loci for NSCL/P were identified by a genome-wide association scan (GWAS) in a German population with subsequent independent replication in a mixed European population. The aim of the present study was to investigate whether these newly detected loci confer similar effects in the North-East European Baltic population. A total of 101 NSCL/P patients and 254 controls from Estonia were included. A significant association was observed for rs7078160 (P = 0.0016) at chromosome 10q25, which confirms the association of this locus with NSCL/P in the Baltic population. No significant association was found for the other four loci, a result that may have been attributable to the limited power of the sample.

View Full Article (HTML) Get PDF (94K)