This paper was presented as a Special Lecture at the First Meeting of the European Society for Pigment Cell Research, Sorrento, Italy, October 11–14. 1987
Induction of Melanogenesis Suppression: Cellular Pharmacology and Mode of Differential Action
Article first published online: 1 AUG 2006
Pigment Cell Research
Volume 1, Issue 6, pages 367–374, May 1988
How to Cite
MISHIMA, Y., HATTA, S., OHYAMA, Y. and INAZU, M. (1988), Induction of Melanogenesis Suppression: Cellular Pharmacology and Mode of Differential Action. Pigment Cell Research, 1: 367–374. doi: 10.1111/j.1600-0749.1988.tb00136.x
- Issue published online: 1 AUG 2006
- Article first published online: 1 AUG 2006
- Received January 27, 1988; accepted February 2, 1988.
Recent elucidation of regulatory mechanisms of eu- and pheomelanogenesis has led us towards an exciting new era of melanogenesis control. I will chiefly address our progress on inhibitory control of melanogenesis from the macromolecular level to human skin colour.
In the past, the exploration and search for skin depigmenting agents has been focussed on and initiated from substances which can suppress isolated tyrosinase in vitro. Now, as I have classified below, many new melanogenic inhibitors have been discovered which, in spite of their non-suppressive effect on isolated naked tyrosinase, suppress melanin formation in the living pigment cell in vitro as well as in the natural world. I will also discuss a recently found unique disorder: unilateral suppression of mixed melanogenesis.
- I. Isolated tyrosinase: Suppressive type
- 1Chemical inhibitors, e.g., kojic acid, ascorbic acid
- 2Naturally occurring inhibitors, e.g., indole blocking factor
- II. Isolated tyrosinase: Nonsuppressive type
- 3Inhibition of tyrosinase synthesis in ribosome
- 4Inhibition of tyrosinase transfer to premelanosomes by glycosylation interruption, e.g., tunicamycin, glucosamine
- 5Melanocyte cytotoxic inhibitors, e.g., hydroquinone, azelaic acid
- III. Congenital unilateral suppression of human mixed melanogenesis
- 6Congenital pheomelanic macular depigmentation