Phylogeny of Regulatory Regions of Vertebrate Tyrosinase Genes

  1. HIROAKI YAMAMOTO1,*,
  2. TOSHIYUKI KUDO1,†,
  3. NORIO MASUKO1,‡,
  4. HIROHITO MIURA1,
  5. SHIGERU SATO1,
  6. MIKA TANAKA1,
  7. SATOSHI TANAKA1,
  8. SAKAE TAKEUCHI2,
  9. SHIGEKI SHIBAHARA1,†,
  10. TAKUJI TAKEUCHI1

Article first published online: 28 JUL 2006

DOI: 10.1111/j.1600-0749.1992.tb00551.x

Issue

Pigment Cell Research

Pigment Cell Research

Volume 5, Issue 5, pages 284–294, November 1992

Additional Information

How to Cite

YAMAMOTO, H., KUDO, T., MASUKO, N., MIURA, H., SATO, S., TANAKA, M., TANAKA, S., TAKEUCHI, S., SHIBAHARA, S. and TAKEUCHI, T. (1992), Phylogeny of Regulatory Regions of Vertebrate Tyrosinase Genes. Pigment Cell Research, 5: 284–294. doi: 10.1111/j.1600-0749.1992.tb00551.x

Author Information

  1. 1

    Biological Institute, Faculty of Science, Tohoku University

  2. 2

    Department of Applied Physiology, Tohoku University School of Medicine; Sendai, Japan

  1. †

    Itoham foods inc., 1–2, Kubogaoka, Moriya-machi, Kitasouma-gun, Ibaraki 302-01, Japan.

  2. ‡

    Taiho Pharmaceutical Co., Hannou, Saitama 357, Japan.

*Hiroaki Yamamoto, Biological Institute, Faculty of Science,Ibhoku University, Aoba-yama, Sendai 980, Japan.

Publication History

  1. Issue published online: 28 JUL 2006
  2. Article first published online: 28 JUL 2006
  3. Received February 29, 1992; accepted July 1, 1992.

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Keywords:

  • Cloning;
  • Gel retardation assay;
  • Japanese quail;
  • Snapping turtle;
  • South-Western blotting

Highly homologous DNA elements were found to be shared by the upstream regions of the mouse tyrosinase and tyrosinase related protein (TRP-1) genes. Several nuclear proteins were shown to bind to both of these upstream regions. Shared homologous DNA elements were also found in the 5’ flanking sequences of Japanese quail and snapping turtle tyrosinase genes. Shared homologous nucleotide sequences were found to be scattered like an archipelago in the 5’ upstream regions of mouse and human tyrosinase genes. Comparisons between Japanese quail and snapping turtle tyrosinase genes gave similar results. On the contrary, mammalian (mouse and human) and nonmammalian (quail and snapping turtle) tyrosinase genes did not show significant homology in their 5’ upstream regions. In contrast, coding sequences in the first exons of vertebrate tyrosinase genes and their deduced amino acid sequences were found to be highly conserved except for their putative leader sequence-coding regions.

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