Chemotactic activity in periodontal disease

I. The role of complement in monocyte chemotaxis

Authors

  • H. Okada,

    1. Dental Research Center adn Deparment of Periodontics, School of Dentistry and Department of Bacteriology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.
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  • M. S. Silverman

    Corresponding author
    1. Dental Research Center adn Deparment of Periodontics, School of Dentistry and Department of Bacteriology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.
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Address: Dr. Myron S. Silverman Dental Research Centre University of North Carolina at Chapel Hill Chapel HIll, North Carolina 27514 U.S.A.

Abstract

Extracts of gingival tissue obtained from periodontal patients, but not from patients with clinically jealthu tissue, were found to be chemotactic for human mononuclear cells. The chemotactic activity of the extracts could be suppressed by anti-C5 serum. The data obtained suggest that C5-related compound are major factors in the chemotaxis of mono nuclear cells in periodontal disease.

Ancillary