Role of fibroblast subpopulations in periodontal physiology and pathology

Authors

  • Christopher A. G. McCulloch,

    Corresponding author
    1. Faculty of Dentistry, University of Toronto, Toronto, Canada
      C. A. G. McCulloch Faculty of Dentistry University of Toronto 124 Edward Street Toronto, Ontario, Canada MSG 1G6
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  • Sandra Bordin

    1. Department of Periodontics, University of Washington, Seattle, Washington, U.S.A.
    2. Research Center in Oral Biology, University of Washington, Seattle, Washington, U.S.A.
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  • This study was supported by MRC (Canada) MA-8903 and by (USA) NIH, iNIDR DE08229-03

C. A. G. McCulloch Faculty of Dentistry University of Toronto 124 Edward Street Toronto, Ontario, Canada MSG 1G6

Abstract

Fibroblasts are the principal cell type in the soft connective tissues of the periodontium; they perform important functions in development, physiology, and disease. A growing number of reports have indicated site-specific phenotypic variation of fibroblasts. Heterogeneity of metabolic traits has been demonstrated in cells from healthy and diseased tissues. The tissue distribution and relative proportions of fibroblast subpopulations have a significant impact on the regulation of connective tissue function in health and disease.

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