Part of this work was presented at the VIth International Conference on Tooth Morphogenesis and Differentiation, 1997, Göteborg, Sweden.
Alkaline phosphatase activity in human periodontal ligament: age effect and relation to cementum growth rate*
Article first published online: 30 JUN 2006
Journal of Periodontal Research
Volume 34, Issue 1, pages 1–6, January 1999
How to Cite
van den Bos, T. and Beertsen, W. (1999), Alkaline phosphatase activity in human periodontal ligament: age effect and relation to cementum growth rate. Journal of Periodontal Research, 34: 1–6. doi: 10.1111/j.1600-0765.1999.tb02215.x
- Issue published online: 30 JUN 2006
- Article first published online: 30 JUN 2006
- Accepted for publication June 25, 1998
- root cementum;
- periodontal ligament;
- alkaline phosphatase;
Recently, a relationship was demonstrated between the thickness of the cementum layer in rat molars and the activity of alkaline phosphatase (ALP) in the adjoining periodontal ligament (PDL). It was the aim of the present study to investigate whether such a relationship also exists in the periodontium of man. Healthy deciduous and permanent teeth free from periodontitis were obtained from 74 patients, varying in age from 3 to 78 yr, and their PDL dissected from the middle one-third of the roots. ALP activity was measured in PDL extracts and expressed per hydroxyproline content. It was shown that ALP activity was relatively high in children. After puberty its concentration decreased to level off at about half the concentration found in the younger age groups. The activity of the enzyme in the PDL correlated positively with the yearly cementum thickness increment as calculated from data published previously.