Enhanced monocyte migration and pro-inflammatory cytokine production by Porphyromonas gingivalis infection
Version of Record online: 23 SEP 2009
© 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard
Journal of Periodontal Research
Volume 45, Issue 2, pages 239–245, April 2010
How to Cite
Pollreisz, A., Huang, Y., Roth, G. A., Cheng, B., Kebschull, M., Papapanou, P. N., Schmidt, A. M. and Lalla, E. (2010), Enhanced monocyte migration and pro-inflammatory cytokine production by Porphyromonas gingivalis infection. Journal of Periodontal Research, 45: 239–245. doi: 10.1111/j.1600-0765.2009.01225.x
- Issue online: 22 FEB 2010
- Version of Record online: 23 SEP 2009
- Accepted for publication March 13, 2009
- Porphyromonas gingivalis;
- periodontal disease;
Pollreisz A, Huang Y, Roth GA, Cheng B, Kebschull M, Papapanou PN, Schmidt AM, Lalla E. Enhanced monocyte migration and pro-inflammatory cytokine production by Porphyromonas gingivalis infection. J Periodont Res 2009; doi: 10.1111/j.1600-0765.2009.01225.x. © 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard
Background and Objective: Porphyromonas gingivalis, a major periodontal pathogen, has been reported to be involved in atherogenesis. In order to further understand this pathogen’s link with systemic inflammation and vascular disease, we investigated its influence on murine monocytes and macrophages from three different sources.
Material and Methods: Concanavalin A-elicited peritoneal macrophages, peripheral blood monocyte-derived macrophages and WEHI 274.1 monocytes were infected with either P. gingivalis 381 or its non-invasive fimbriae-deficient mutant, DPG3.
Results: Infection with P. gingivalis 381 markedly induced monocyte migration and significantly enhanced production of the pro-inflammatory cytokines, tumor necrosis factor-α and interleukin-6. Consistent with a role for this pathogen’s major fimbriae and/or its invasive capacity, infection with DPG3 had a minimal effect on both monocyte attraction and pro-inflammatory cytokine production.
Conclusion: Since monocyte recruitment and activation are important steps in the development of vascular inflammation and atherosclerosis, these results suggest that P. gingivalis infection may be involved in these processes.