Reaction of Cationic Groups of Chlorpromazine with Anionic Macromolecules: Complexes with DNA, RNA, Hyaluronic Acid and Heparin

Authors

  • N. Blumenkrantz,

    1. University of Copenhagen, Department of Dermatology (with Connective Tissue Research Laboratories), Rigshospitalet, Blegdamsvej, DK-2100 Copenhagen, Denmark
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  • G. Asboe-Hansen

    1. University of Copenhagen, Department of Dermatology (with Connective Tissue Research Laboratories), Rigshospitalet, Blegdamsvej, DK-2100 Copenhagen, Denmark
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Abstract

Abstract: In vitro, chlorpromazine forms complexes with DNA, RNA, hyaluronic acid and heparin. Irradiation with ultraviolet light induces chemical degradation of chlorpromazine. These phenomena are discussed in relation to chlorpromazine-induced lupoid syndrome with antinuclear factors in the blood serum of human patients as well as to photo-toxic and photo-allergic dermatoses.

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