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Keywords:

  • Chlorpromazine;
  • DNA;
  • RNA;
  • hyaluronic acid;
  • heparin;
  • anionic macromolecules

Abstract: In vitro, chlorpromazine forms complexes with DNA, RNA, hyaluronic acid and heparin. Irradiation with ultraviolet light induces chemical degradation of chlorpromazine. These phenomena are discussed in relation to chlorpromazine-induced lupoid syndrome with antinuclear factors in the blood serum of human patients as well as to photo-toxic and photo-allergic dermatoses.