Localization of Oestradiol in the Rat Nasal Mucosa


  • Eva B. Brittebo

    1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala Biomedical Center, Box 573, S–751 23 Uppsala, Sweden
    Search for more papers by this author


Abstract: The metabolism of 4–14C–oestradiol in the rodent respiratory tract has been investigated in vitro. Using thin–layer radiochromatography, at least 3 and 2 metabolites were found at incubation with slices from the rat olfactory mucosa and lung, respectively. Autoradiography of the nasal region of rats injected intravenously with 4–14C–oestradiol showed a high level of radioactivity in the mucosa covering the respiratory region, and in the subepithelial parts of the olfactory mucosa. Autoradiography of rat and mouse lung slices incubated with 4–14C–oestradiol showed that a selective localization of radioactivity occurred in the bronchial mucosa. The radioactivity in the mucosa of the respiratory tract was reversibly bound and could be extracted with organic solvents