The perilesional skin in vitiligo: a colorimetric in vivo study of 25 patients

Authors

  • V. Brazzelli,

    1. Department of Human and Hereditary Pathology, Institute of Dermatology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, and
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  • F. Muzio,

    1. Department of Human and Hereditary Pathology, Institute of Dermatology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, and
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  • M. Antoninetti,

    1. Department of Human and Hereditary Pathology, Institute of Dermatology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, and
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  • S. Villani,

    1. Department of Health Sciences, Section of Medical Statistics and Epidemiology, University of Pavia, Pavia, Italy
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  • F. Donadini,

    1. Department of Human and Hereditary Pathology, Institute of Dermatology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, and
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  • A. Altomare,

    1. Department of Human and Hereditary Pathology, Institute of Dermatology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, and
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  • G. Borroni

    1. Department of Human and Hereditary Pathology, Institute of Dermatology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, and
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  • Conflicts of interest:
    None declared.

Correspondence:
Valeria Brazzelli, M.D., Clinica Dermatologica, Fondazione IRCCS Policlinico S. Matteo, Università di Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.
Tel: +39 3 8250 3794
Fax: +39 3 8252 6379
e-mail: vbrazzelli@libero.it

Abstract

Background: The aim of this work was to study in vivo the perilesional skin in vitiligo with a colorimetric method.

Methods: Twenty-five patients affected by vitiligo were included. For each patient, three different areas were considered: the lesional, the perilesional and the normal skin as far as 5 cm from the nearest vitiligo spot. Skin pigmentation measurements were performed with a chromameter.

Results: The results showed that luminance L* decreased significantly in relation to increasing distance from the vitiligo spot. As expected, L* in the vitiligo spot was significantly higher than in the perilesional (P<0.0001) and normal skin (P<0.0001). There was a small difference in L* between normal skin as far as 5 cm from the nearest vitiligo spot and perilesional skin. In contrast, the pigmentation index (b*) gradually increased from lesional to perilesional to normal skin. Furthermore, the comparison of the b* value between the normal skin as far as 5 cm from the nearest vitiligo spot was higher than perilesional skin and it was statistically significant (P<0.0001).

Conclusion: Our results in vivo underline that the perilesional skin near the vitiligo spot is lighter than normal skin as far as 5 cm from the vitiligo spot.

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