Conflicts of interest: None declared.
Psoralen and ultraviolet A in the treatment of granuloma annulare
Article first published online: 10 MAR 2011
© 2011 John Wiley & Sons A/S
Photodermatology, Photoimmunology & Photomedicine
Volume 27, Issue 2, pages 81–84, April 2011
How to Cite
Browne, F., Turner, D. and Goulden, V. (2011), Psoralen and ultraviolet A in the treatment of granuloma annulare. Photodermatology, Photoimmunology & Photomedicine, 27: 81–84. doi: 10.1111/j.1600-0781.2011.00574.x
- Issue published online: 10 MAR 2011
- Article first published online: 10 MAR 2011
- Accepted for publication: 24 November 2010
- Granuloma annulare;
Background: Granuloma annulare (GA) is a benign, usually self-limiting disease. Lesions may be localized or generalized with a tendency for generalized disease to follow a chronic course. There is evidence to support psoralen and ultraviolet A (PUVA) in the treatment of GA, but little data on long-term benefits. The purpose of this study was to investigate the effect of PUVA in the treatment of GA, and to establish clearance and remission rates.
Methods: We carried out a retrospective study of patients with generalized GA treated with PUVA over 13 years. Data were collected from case notes and a phototherapy database. On completion of treatment, outcome was assessed as clear, good improvement, moderate improvement and poor outcome. Follow-up data were obtained for patients who had cleared using a postal questionnaire in addition to clinic notes.
Results: Fifty per cent of courses resulted in clearance of disease, 16% in good improvement, 25% had moderate benefit and 9% had a poor outcome. Of the patients that cleared, 79% remained in remission at 6 months but only 32% were still clear 12 months following treatment.
Conclusion: Our findings show clearance or good improvement of generalized GA in 66% of cases. Prolonged remission, however, occurred in less than a third of patients.