Comparison of the Effects of β-Adrenergic Agents on Pineal Serotonin N-Acetyltransferase Activity and Melatonin Content in Two Species of Hamsters
Article first published online: 30 JAN 2007
Journal of Pineal Research
Volume 1, Issue 1, pages 23–30, January 1984
How to Cite
Steinlechner, S., King, T. S., Champney, T. H., Spanel-Borowski, K. and Reiter, R. J. (1984), Comparison of the Effects of β-Adrenergic Agents on Pineal Serotonin N-Acetyltransferase Activity and Melatonin Content in Two Species of Hamsters. Journal of Pineal Research, 1: 23–30. doi: 10.1111/j.1600-079X.1984.tb00192.x
- Issue published online: 30 JAN 2007
- Article first published online: 30 JAN 2007
- Received September 6, 1983; accepted November 23, 1983.
- pineal gland;
The nighttime rise in pineal melatonin levels can be blocked by administration of the β-adrenergic receptor antagonist, propranolol, in both Syrian hamsters and rats. Although the administration of β-adrenergic receptor agonists such as norepinephrine or isoproterenol stimulates pineal melatonin production in the rat, these drugs are without apparent effect on indole production in the Syrian hamster. To determine whether this lack of stimulatory effect in the Syrian hamster is characteristic of this species, a comparison of the effects of norepinephrine and isoproterenol on pineal serotonin N-acetyltransferase activity and melatonin content was conducted. In contrast to their lack of effect in the Syrian hamster, norepinephrine and isoproterenol stimulated pineal serotonin N-acetyltransferase activity and melatonin content in the Djungarian hamster. Hourly injection of norepinephrine during a continuation of light into the normal dark period stimulated increases in the activity of serotonin N-acetyltransferase and melatonin content in the Djungarian hamster but was without effect on these pineal parameters in the Syrian hamster.