Pinealectomy Has No Effect on Diet-Induced Thermogenesis and Brown Adipose Tissue Proliferation in Rats
Article first published online: 30 JAN 2007
Journal of Pineal Research
Volume 1, Issue 1, pages 69–74, January 1984
How to Cite
Viswanathan, M. and George, J. C. (1984), Pinealectomy Has No Effect on Diet-Induced Thermogenesis and Brown Adipose Tissue Proliferation in Rats. Journal of Pineal Research, 1: 69–74. doi: 10.1111/j.1600-079X.1984.tb00196.x
- Issue published online: 30 JAN 2007
- Article first published online: 30 JAN 2007
- Received August 30, 1983; accepted January 4, 1984.
- brown adipose tissue;
- diet-induced thermogenesis;
The role of the pineal gland in diet-induced thermogenesis (DIT) and growth of brown adipose tissue (BAT) in rats during voluntary overfeeding was studied using pinealectomized and sham-pinealectomized rats. Overfeeding was induced by offering the animals a cafeteria-diet (CD) which contained a selection of highly palatable food items. Rats which were fed CD had significantly increased interscapular brown adipose tissue (IBAT) mass and increased tail-skin temperature indicating the importance of the tail in thermoregulation during DIT. Pinealectomy had no effect on the increase in tail-skin temperature and deposition of IBAT, which were stimulated by CD feeding. These findings suggest that the pineal is not directly involved in modulating the metabolism of BAT in rats.