Human Melatonin Production Decreases With Age
Article first published online: 30 JAN 2007
Journal of Pineal Research
Volume 3, Issue 4, pages 379–388, October 1986
How to Cite
Sack, R. L., Lewy, A. J., Erb, D. L., Vollmer, W. M. and Singer, C. M. (1986), Human Melatonin Production Decreases With Age. Journal of Pineal Research, 3: 379–388. doi: 10.1111/j.1600-079X.1986.tb00760.x
- Issue published online: 30 JAN 2007
- Article first published online: 30 JAN 2007
- Received November 19, 1985; accepted April 11, 1986.
- pineal gland;
- seasonal rhythms;
- demographic variables;
The purpose of this study was to investigate the effects of time of year and demographic variables on the amplitude of melatonin production in normal human subjects. Melatonin production was estimated by measuring the overnight excretion of its major urinary metabolite, 6-hydroxymelatonin. Urine was collected on three consecutive nights in the summer from a sample of 60 normal subjects balanced for sex and age. The collections were repeated in a subgroup during the winter. Melatonin production clearly declined with age but was not influenced by other demographic variables or by season of the year.