High melatonin solubility in aqueous medium
Version of Record online: 30 JAN 2007
Journal of Pineal Research
Volume 16, Issue 4, pages 198–201, May 1994
How to Cite
Shida, CS., Castrucci, A. M. L. and Lamy-Freund, M. T. (1994), High melatonin solubility in aqueous medium. Journal of Pineal Research, 16: 198–201. doi: 10.1111/j.1600-079X.1994.tb00102.x
- Issue online: 30 JAN 2007
- Version of Record online: 30 JAN 2007
- Received December 14, 1993; accepted February 23, 1994.
- aqueous solubility;
- time stability
Shida CS, Castrucci AML, Lamy-Freund MT. High melatonin solubility in aqueous medium. J Pineal Res. 1994:16:198–201.
The pineal hormone melatonin (5-methoxy-N-acetyl-tryptamine) has been reported to participate in important physiological processes. Although some of its biological actions seem to depend on a protein receptor at the membrane surface, melatonin is known to interact with a large variety of tissues and cells, suggesting that the molecule may not necessarily interact through a specific membrane receptor at a specific cell. Most discussions of melatonin activity have assumed that the molecule is highly hydrophobic. Contrary to belief, the present work shows that melatonin is soluble in a purely aqueous medium up to 5 ± 10-3 M and describes a new method of melatonin preparation which shows the high hydrophilicity of the molecule. The results presented will affect the current biological hypothesis on the need of a melatonin carrier in the blood stream or the mechanisms which allow the hormone to cross the cell membrane and interact at the level of the nucleus.