Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide

Authors

  • Juan M. Guerrero,

    1. Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, U.S.A.
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  • Russel J. Reiter,

    Corresponding author
    1. Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, U.S.A.
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  • Burkhard Poeggeler,

    1. Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, U.S.A.
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  • Li-Dun Chen,

    1. Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, U.S.A.
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  • Dun-Xian Tan

    1. Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, U.S.A.
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Address reprint requests to Russel J. Reiter, Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284-7762 U.S.A.

Abstract

Guerrero JM, Reiter RJ, Poeggeler B, Chen L-D, Tan D-X. Elevation of cyclic GMP levels in the rat pineal gland induced by nitric oxide. J Pineal Res. 1994:16:210–214.

Abstract

The present paper reports that nitric oxide (NO) released by sodium nitroprusside (SNP) is a potent activator of rat pineal cyclic GMP production without affecting cyclic AMP synthesis. Other drugs such as isoproterenol, vasoactive intestinal peptide, and peptide histidine isoleucine were ineffective in stimulating cyclic GMP production, but activated cyclic AMP production. However, L-arginine, the physiological precursor of NO, did not activate either cyclic GMP or NO synthesis. Because L-arginine failed to activate cyclic GMP production, results suggest that NO is not produced in the pineal gland, but behaves as a potent regulator of this cyclic nucleotide.

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