Nocturnal plasma melatonin concentrations in healthy volunteers: Effect of single doses of d-fenfluramine, paroxetine, and ipsapirone
Article first published online: 30 JAN 2007
Journal of Pineal Research
Volume 21, Issue 2, pages 55–58, September 1996
How to Cite
Nathan, P. J., Norman, T. R. and Burrows, G. D. (1996), Nocturnal plasma melatonin concentrations in healthy volunteers: Effect of single doses of d-fenfluramine, paroxetine, and ipsapirone. Journal of Pineal Research, 21: 55–58. doi: 10.1111/j.1600-079X.1996.tb00271.x
- Issue published online: 30 JAN 2007
- Article first published online: 30 JAN 2007
- Received February 28,1996; accepted April 30,1996.
- indirectly acting serotonin agonist;
- 5-HTu partial agonist- d-fenfluramine;
Abstract: The effect on nocturnal melatonin secretion of acute administration of the indirectly acting serotonin (5-HT) receptor agonists d-fenfluramine (30 mg) and paroxetine (20 mg) and a partial 5-HT1A receptor agonist ipsapirone (20 mg) was investigated in healthy male volunteers and compared to a placebo condition. Each subject (n=8) received each drug on one occasion over a 4 week study period, with drug administration separated by 1 week. A randomized, counter-balanced design was used. Drugs or placebo were administered at 2,000 hours in the light, and all blood samples were collected throughout the night in the dark at regular intervals until 0600 hours. Neither d-fenfluramine, paroxetine, or ipsapirone following acute dosage had a statistically significant effect on nocturnal melatonin synthesis. The lack of effect seen with d-fenfluramine, paroxetine, and ipsapirone may be due to limitations imposed by the dose requirements.