Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage
Article first published online: 14 JUN 2004
Journal of Pineal Research
Volume 37, Issue 3, pages 149–152, October 2004
How to Cite
Ates, B., Yilmaz, I., Geckil, H., Iraz, M., Birincioglu, M. and Fiskin, K. (2004), Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage. Journal of Pineal Research, 37: 149–152. doi: 10.1111/j.1600-079X.2004.00148.x
- Issue published online: 14 JUN 2004
- Article first published online: 14 JUN 2004
- Received February 19, 2004; accepted May 7, 2004.
- antioxidative enzymes;
- free radicals;
- intestinal ischemia-reperfusion;
- oxidative stress
Abstract: Tissue injury resulting from ischemia-reperfusion is of fundamental importance. Experimental evidence suggests that the generation of reactive oxygen species is significantly responsible for this type of injury. In the present study, besides investigating the protective role of melatonin on tissue damage caused by intestinal ischemia-reperfusion, the protective activity of this compound was also analyzed in both pre- and post ischemia melatonin-treated rats. The activities of the main antioxidative enzymes, catalase, superoxide dismutase and glutathione peroxidase in the intestine showed significant (P < 0.05) increases in melatonin-treated animals that were subjected to ischemia/reperfusion compared with those subjected only to ischemia/reperfusion. Also, results clearly indicate that the level of malondialdeyhde, an index of lipid peroxidation, decreased significantly (P < 0.05) when rats subjected to intestinal/reperfusion were given melatonin either before ischemia or before reperfusion.