Melatonin as a local regulator of human placental function
Article first published online: 23 MAY 2005
Journal of Pineal Research
Volume 39, Issue 3, pages 261–265, October 2005
How to Cite
Iwasaki, S., Nakazawa, K., Sakai, J., Kometani, K., Iwashita, M., Yoshimura, Y. and Maruyama, T. (2005), Melatonin as a local regulator of human placental function. Journal of Pineal Research, 39: 261–265. doi: 10.1111/j.1600-079X.2005.00244.x
- Issue published online: 23 MAY 2005
- Article first published online: 23 MAY 2005
- Received April 12, 2002; accepted April 8, 2005.
- human chorionic gonadotropin;
Abstract: Melatonin plays a critical role in a variety of mammalian reproductive processes not only acting on the central nervous system but also behaving as a peripheral physiologic regulator. To address the relevance of melatonin to the maintenance of pregnancy at the feto-maternal interface, we investigated the expression of two types of membrane melatonin receptors, MT1 and MT2, as well as arylalkylamine N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT), the two enzymes required for the conversion of serotonin to melatonin, in the human placenta and the effect of melatonin on the release of human chorionic gonadotropin (hCG) from cultured human trophoblast cells. RT-PCR analysis and DNA sequencing revealed that transcripts of MT1, MT2, AA-NAT, and HIOMT were present in the first-trimester human placenta. We also found that melatonin significantly potentiated hCG secretion at optimal concentrations. These results suggest that melatonin may regulate human placental function in a paracrine/autocrine manner, providing evidence for a novel role in human reproduction.