Melatonin stimulates osteointegration of dental implants
Version of Record online: 19 FEB 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Journal of Pineal Research
Volume 45, Issue 2, pages 174–179, September 2008
How to Cite
Cutando, A., Gómez-Moreno, G., Arana, C., Muñoz, F., Lopez-Peña, M., Stephenson, J. and Reiter, R. J. (2008), Melatonin stimulates osteointegration of dental implants. Journal of Pineal Research, 45: 174–179. doi: 10.1111/j.1600-079X.2008.00573.x
- Issue online: 12 AUG 2008
- Version of Record online: 19 FEB 2008
- Received December 20, 2007; accepted January 14, 2008.
- Beagle dogs;
- oral cavity;
Abstract: The aim of this study was to evaluate the effect of the topical application of melatonin on osteointegration of dental implants in Beagle dogs 14 days after their insertion. In preparation for subsequent insertion of dental implants, upper and lower premolars and molars were extracted from 12 Beagle dogs. Each mandible received cylindrical screw implants of 3.25 mm in diameter and 10 mm in length. The implants were randomly assigned to the mesial and distal sites on each side of the mandible. Prior to implanting, 1.2 mg lyophylized powdered melatonin was applied to one bone hole at each side of the mandible. None was applied at the control sites. Eight histological sections per implant were obtained for histomorphometric studies. After a 2-wk treatment period, melatonin significantly increased the perimeter of bone that was in direct contact with the treated implants (P < 0.0001), bone density (P < 0.0001), new bone formation (P < 0.0001) and inter-thread bone (P < 0.05) in comparison with control implants. Topical application of melatonin may act as a biomimetic agent in the placement of endo-osseous dental implants.