Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients

  1. Kornelia Kędziora-Kornatowska1,
  2. Karolina Szewczyk-Golec2,
  3. Mariusz Kozakiewicz2,
  4. Hanna Pawluk2,
  5. Jolanta Czuczejko2,
  6. Tomasz Kornatowski3,
  7. Grzegorz Bartosz4,
  8. Józef Kędziora2

Article first published online: 11 FEB 2009

DOI: 10.1111/j.1600-079X.2009.00666.x

Issue

Journal of Pineal Research

Journal of Pineal Research

Volume 46, Issue 3, pages 333–337, April 2009

Additional Information

How to Cite

Kędziora-Kornatowska, K., Szewczyk-Golec, K., Kozakiewicz, M., Pawluk, H., Czuczejko, J., Kornatowski, T., Bartosz, G. and Kędziora, J. (2009), Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients. Journal of Pineal Research, 46: 333–337. doi: 10.1111/j.1600-079X.2009.00666.x

Author Information

  1. 1

    Department and Clinic of Geriatrics

  2. 2

    Department of Biochemistry

  3. 3

    Department of Pharmacology and Therapy, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland

  4. 4

    Department of Molecular Biophysics, University of Łódź, Łódź, Poland

*Address reprint requests to Józef Kędziora, Professor of Medicine, Department of Biochemistry, Nicolaus Copernicus University Collegium Medicum, 24 Karłowicza Street, PL 85-092 Bydgoszcz, Poland. E-mail: kasiakor@interia.pl

Publication History

  1. Issue published online: 13 MAR 2009
  2. Article first published online: 11 FEB 2009
  3. Received October 15, 2008; accepted December 30, 2008.

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Keywords:

  • aging;
  • antioxidants;
  • antioxidative enzymes;
  • hyperglycemia;
  • melatonin;
  • oxidative stress;
  • type 2 diabetes mellitus

Abstract:  An elevated oxidative status in the aging organism may be involved in the development of non-insulin dependent diabetes mellitus (NIDDM). Melatonin, a potent antioxidant agent, is essential for glucose homeostasis and regulation. The aim of this study was to determine the influence of melatonin supplementation on the oxidative stress parameters in elderly NIDDM patients. The malondialdehyde (MDA) concentration, Cu-Zn superoxide dismutase (SOD-1) activity in erythrocytes, the level of nitrate/nitrite in plasma and morning melatonin concentration and oxidase activity of ceruloplasmin (Cp) in serum in 15 elderly NIDDM patients at baseline and after the 30 days of melatonin supplementation (5 mg daily) in comparison with levels in 15 healthy elderly volunteers were determined. A significant increase of MDA level and decrease of SOD-1 activity and melatonin concentration were observed in NIDDM patients. Cp oxidase activity and nitrate/nitrite level were similar in both examined groups. Melatonin administration in NIDDM patients resulted in a significant increase in the morning melatonin concentration and SOD-1 activity, and a reduction in the MDA level and Cp oxidase activity. Statistically significant alterations in nitrate/nitrite levels were not observed. These results indicate an improvement of antioxidative defense after melatonin supplementation in the NIDDM individuals and suggest melatonin supplementation as an additional treatment for the control of diabetic complications.

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