Melatonin reduces cardiac inflammatory injury induced by acute exercise
Article first published online: 13 JUL 2009
© 2009 The Authors. Journal compilation © 2009 John Wiley & Sons A/S
Journal of Pineal Research
Volume 47, Issue 2, pages 184–191, September 2009
How to Cite
Veneroso, C., Tuñón, M. J., González-Gallego, J. and Collado, P. S. (2009), Melatonin reduces cardiac inflammatory injury induced by acute exercise. Journal of Pineal Research, 47: 184–191. doi: 10.1111/j.1600-079X.2009.00699.x
- Issue published online: 2 AUG 2009
- Article first published online: 13 JUL 2009
- Received April 30, 2009; accepted June 4, 2009.
Abstract: Cardiac muscle tissue, when stimulated by acute exercise, presents increased signs of cell damage. This study was designed to investigate whether overexpression of inflammatory mediators induced in the heart by acute exercise could be prevented by melatonin and whether the protective effect of melatonin was related with inhibition of nuclear factor kappa B (NF-κB) activation. Male Wistar rats received melatonin i.p. at a dose of 1.0 mg/kg body weight 3 min before being exercised for 60 min on a treadmill at a speed of 25 m/min and a 10% slope. Exercise was associated with a significant increase in myeloperoxidase activity and in TNF-α, IL-1 and IL-6 mRNA levels. Both mRNA level and protein concentrations of intercellular adhesion molecule-1, inducible nitric oxide synthase, and cyclooxygenase-2 were also significantly elevated. A significant activation of nuclear factor kappa B (NF-κB) was observed in exercised rats. These effects were totally or partially prevented by melatonin administration. Data obtained indicate that melatonin protects against heart damage caused by acute exercise. Impaired production of noxious mediators involved in the inflammatory process and down-regulation of the NF-κB signal transduction pathway appear to contribute to the beneficial effects of melatonin.