Matrix metalloproteinases in health and disease: regulation by melatonin
Article first published online: 21 OCT 2010
© 2010 The Authors. Journal of Pineal Research © 2010 John Wiley & Sons A/S
Journal of Pineal Research
Volume 50, Issue 1, pages 8–20, January 2011
How to Cite
Swarnakar, S., Paul, S., Singh, L. P. and Reiter, R. J. (2011), Matrix metalloproteinases in health and disease: regulation by melatonin. Journal of Pineal Research, 50: 8–20. doi: 10.1111/j.1600-079X.2010.00812.x
- Issue published online: 9 DEC 2010
- Article first published online: 21 OCT 2010
- Received July 9, 2010; accepted August 16, 2010.
- matrix metalloproteinase;
- redox signaling
Abstract: Matrix metalloproteinases (MMPs) are part of a superfamily of metal-requiring proteases that play important roles in tissue remodeling by breaking down proteins in the extracellular matrix that provides structural support for cells. The intricate balance in protease/anti-protease stoichiometry is a contributing factor in a number of diseases. Melatonin possesses multifunctional bioactivities including antioxidative, anti-inflammatory, endocrinologic and behavioral effects. As melatonin affects the redox status of tissues, the association of reactive oxygen species (ROS) with tissue injury under different circumstances may be mitigated by melatonin. Redox signaling is expanding into all areas of basic and clinical sciences, and this timely review focuses on the topic of regulation of MMP activities by melatonin. This is a rapidly growing field. Accumulating evidence indicates that oxidative stress plays an important role in regulating the activities of MMPs that are involved in various cellular processes such as cellular proliferation, angiogenesis, apoptosis, invasion and metastasis. This review offers sections on MMPs, melatonin, major physiological and pathophysiological conditions in the context to MMPs, followed by redox signaling mechanisms that are known to influence the cellular processes. Finally, we discuss the emerging molecular mechanisms relevant to regulatory actions of melatonin on the activities of MMPs. The possibility that melatonin might have therapeutic significance via regulation of MMPs may be a novel approach in the treatment of some diseases.