Dr Xiao-Jing Lin, Dr Gui-Ping Mei, Dr Ting-Bao Zhao and Dr Jian Liu have equally contributed to this study.
Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats
Article first published online: 11 MAR 2011
© 2011 John Wiley & Sons A/S
Journal of Pineal Research
Volume 50, Issue 4, pages 436–444, May 2011
How to Cite
Lin, X.-J., Mei, G.-P., Liu, J., Li, Y.-L., Zuo, D., Liu, S.-J., Zhao, T.-B. and Lin, M.-T. (2011), Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats. Journal of Pineal Research, 50: 436–444. doi: 10.1111/j.1600-079X.2011.00863.x
- Issue published online: 12 APR 2011
- Article first published online: 11 MAR 2011
- Accepted manuscript online: 1 FEB 2011 09:37AM EST
- Received January 3, 2011;, accepted January 20, 2011.
- free radicals;
- multiple organ dysfunction syndrome;
- septic shock
Abstract: Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock. Heatstroke resembles septic shock in many aspects. Thus, this study was performed on the anesthetized rats by using heat exposure to induce heatstroke-associated MODS. We evaluated the effect of melatonin, a versatile molecule synthesized in the pineal gland and in many organs, in heatstroke rats and showed that melatonin (0.2–5.0 mg/kg of body weight, i.v., immediately after the start of heat stress) significantly (i) attenuated hyperthermia, hypotension and hypothalamic ischemia and hypoxia, (ii) reduced plasma index of the toxic oxidizing radicals like nitric oxide metabolites and hydroxyl radicals, (iii) diminished plasma index of hepatic and renal dysfunction like creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase, (iv) attenuated plasma systemic inflammation response molecules like soluble intercellular and lesion molecule-1, E-selectin, tumor necrosis factor-alpha, interleukin (IL)-1β, and IL-6, (v) promoted plasma levels of an anti-inflammatory cytokine IL-10, (vi) reduced an index of infiltration of polymorphonuclear neutrophils in the lung like myeloperoxidase activity, and (vii) promoted the survival time to fourfold compared with the heatstroke alone group. Thus, melatonin could be a novel agent for the treatment of heatstroke animals or patients in the early stage.