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Sustained release of melatonin from poly (lactic-co-glycolic acid) (PLGA) microspheres to induce osteogenesis of human mesenchymal stem cells in vitro

  1. Liangming Zhang1,†,
  2. Jinling Zhang2,†,
  3. You Ling3,
  4. Changhua Chen2,
  5. Anjing Liang1,
  6. Yan Peng1,
  7. Hong Chang2,
  8. Peiqiang Su4,
  9. Dongsheng Huang1

Article first published online: 19 JUN 2012

DOI: 10.1111/j.1600-079X.2012.01016.x

Issue

Journal of Pineal Research

Journal of Pineal Research

Volume 54, Issue 1, pages 24–32, January 2013

Additional Information

How to Cite

Zhang, L., Zhang, J., Ling, Y., Chen, C., Liang, A., Peng, Y., Chang, H., Su, P. and Huang, D. (2013), Sustained release of melatonin from poly (lactic-co-glycolic acid) (PLGA) microspheres to induce osteogenesis of human mesenchymal stem cells in vitro. Journal of Pineal Research, 54: 24–32. doi: 10.1111/j.1600-079X.2012.01016.x

Author Information

  1. 1

    Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China

  2. 2

    School of Life Science, Sun Yat-Sen University, Guangzhou, China

  3. 3

    School of Materials Science and Engineering, South China University of Technology, Guangzhou, China

  4. 4

    Department of Orthopedics, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

  1. †

    These authors contributed equally to this study.

*Address reprint requests to Dongsheng Huang, Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China. E-mail: huangdongshen18@hotmail.com or Peiqiang Su, Department of Orthopedics, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. E-mail: spq88007@yahoo.com.cn

  1. †

    These authors contributed equally to this study.

Publication History

  1. Issue published online: 6 DEC 2012
  2. Article first published online: 19 JUN 2012
  3. Accepted manuscript online: 31 MAY 2012 11:48AM EST
  4. Received January 31, 2012; , Accepted May 25, 2012.

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Figure S1. Detection of melatonin released from PLGA-MS microspheres by HPLC assay.

Table S1. In vitro release of melatonin from PLGA-MEL-MS microspheres.

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