ONLINE ONLY ARTICLE
Is there an interaction between BDKRB2−9/+9 and GNB3 C825T polymorphisms and elite athletic performance?
Article first published online: 7 JAN 2011
© 2011 John Wiley & Sons A/S
Scandinavian Journal of Medicine & Science in Sports
Volume 21, Issue 6, pages e242–e246, December 2011
How to Cite
Eynon, N., Meckel, Y., Alves, A. J., Nemet, D. and Eliakim, A. (2011), Is there an interaction between BDKRB2−9/+9 and GNB3 C825T polymorphisms and elite athletic performance?. Scandinavian Journal of Medicine & Science in Sports, 21: e242–e246. doi: 10.1111/j.1600-0838.2010.01261.x
- Issue published online: 29 NOV 2011
- Article first published online: 7 JAN 2011
- Accepted for publication 18 October 2010
- top-level athletes;
The −9 deletion allele in the BDKRB2 −9/+9 polymorphism was associated previously with improved endurance performance. We compared the frequency distribution of the BDKRB2 −9/+9 (rs5810761) polymorphism between athletes (n=155) of sports with different demands (endurance runners; n=74 vs sprinters; n=81) as well as between athletes of different competitive levels (elite level; n=46 vs national level; n=109). These results were compared with those of 240 non-athletic healthy individuals. We also tested the influence of the interaction between the BDKRB2 −9/+9 and the GNB3 C825T (rs5443) genotypes in relation to endurance performance. Genotype distribution and allele frequencies were found to be similar in the endurance athlete, sprinter, and control groups (P=0.83 for genotype distribution and P=0.9 for allele frequencies). Similarly, no statistical differences were found between the subgroups of elite-level endurance athletes and national-level endurance athletes, or between elite-level and national-level sprinters (P>0.09 for all comparisons). There was no interaction between BDKRB2 −9/+9 and GNB3 C825T polymorphisms in relation to endurance performance (P=0.16 for interaction effect). In conclusion, the BDKRB2 +9/−9 polymorphism is not associated with endurance performance, at least among Israeli athletes, and the GNB3TT+BDKRB2 −9/−9 “optimal genotype” is not associated with endurance performance.