7-Tesla MR imaging of non-melanoma skin cancer samples: correlation with histopathology
Article first published online: 24 NOV 2011
© 2011 John Wiley & Sons A/S
Skin Research and Technology
Volume 18, Issue 4, pages 413–420, November 2012
How to Cite
Aubry, S., Leclerc, O., Tremblay, L., Rizcallah, E., Croteau, F., Orfali, C. and Lepage, M. (2012), 7-Tesla MR imaging of non-melanoma skin cancer samples: correlation with histopathology. Skin Research and Technology, 18: 413–420. doi: 10.1111/j.1600-0846.2011.00587.x
- Issue published online: 13 OCT 2012
- Article first published online: 24 NOV 2011
- Manuscript Accepted: 9 OCT 2011
- keratinocytic skin cancer;
- basal cell carcinoma;
- squamous cell carcinoma
The aims of this study were to compare in vitro magnetic resonance imaging (MRI) characteristics of keratinocytic skin cancer assessed by a 7-tesla (T) MRI with histopathology, and to describe MRI features of skin tumors.
This prospective study included 30 skin tumors treated by surgery. MR images of skin samples were acquired on a 7-T MR scanner using a fast spin-echo T2-weighted and an isotropic 3D gradient-echo T1-weighted sequence. Length, width, Breslow index and margins of the lesions were measured. The presence or absence of the following was noted: healthy margins, ulceration of the dermis, in situ lesions, superficial and deep dermis involvement, subcutaneous involvement, superficial and intratumoral keratin. MR results were compared to histopathology.
Interclass correlation coefficient (ICC) was very good for the evaluation of the width (ICC = 0.86) and Breslow index (ICC = 0.87). The ICC was good for the evaluation of the margins (ICC = 0.70) but for length, ICC was lower (ICC = 0.67). Mean bias between MRI and histopathology was inferior to 1 mm for width, Breslow index and margin.
In vitro 7-T MRI of keratinocytic skin cancer allows delineation of lesions with good correlation with histopathology. After in vivo confirmation it could have a diagnostic role regarding the delineation of surgical margins but its actual limitations prevent its practical adoption at this time.