Pre-operative assessment of basal cell carcinoma dimensions using high frequency ultrasonography and its correlation with histopathology
Article first published online: 24 JUN 2012
© 2012 John Wiley & Sons A/S
Skin Research and Technology
Volume 19, Issue 1, pages e132–e138, February 2013
How to Cite
Nassiri-Kashani, M., Sadr, B., Fanian, F., Kamyab, K., Noormohammadpour, P., Shahshahani, M. M., Zartab, H., Naghizadeh, M.-M., Sarraf-Yazdy, M. and Firooz, A. (2013), Pre-operative assessment of basal cell carcinoma dimensions using high frequency ultrasonography and its correlation with histopathology. Skin Research and Technology, 19: e132–e138. doi: 10.1111/j.1600-0846.2012.00619.x
- Issue published online: 7 JAN 2013
- Article first published online: 24 JUN 2012
- Manuscript Accepted: 26 APR 2012
- Manuscript Revised: 4 DEC 2011
- Manuscript Received: 10 AUG 2011
- skin cancer;
- high frequency ultrasonography;
- basal cell carcinoma
High frequency ultrasonography (HFUS) is a non-invasive, low risk method which can provide real-time visual information regarding different processes in cutaneous tissue. The goal of this study is to compare the accuracy of HFUS in determining depth and width of basal cell carcinoma (BCC) lesions compared with histopathology as a reference standard.
The depth and width of 56 primary BCCs in various locations were measured in vivo using the ultrasound system device Digital Taberna Promedica (Luneburg, FRG DUB 20 Ultrasound Scanner), with a 50-MHz hand-held transducer and compared with the depth and width reported in histopathologic examination of these lesions after complete excision. The intraclass correlation coefficient (ICC) was calculated using a one-way ANOVA table to compare measured dimensions for the same tumors with the two diagnostic methods.
The mean depth of tumor in HFUS (1353.68 ± 656.456 microns) was lower than the amount measured by the dermatopathologist (1560.71 ± 1044.323 microns). However, the difference was not statistically significant (P > 0.05). The means of largest diameter of tumors in HFUS and pathology were 5996.77 ± 2271.783 and 3891.07 ± 1995.452 microns, respectively (P < 0.001). There was a low correlation in diameter (r = 0.27, P < 0.05) and a moderate correlation in depth (r = 0.45, P < 0.001) of BCCs between these two methods.
HFUS may be a useful method to assess the dimensions of BCC prior to surgery.