Histological correlates of optical coherence tomography in non-melanoma skin cancer
Version of Record online: 28 JUN 2012
© 2012 John Wiley & Sons A/S
Skin Research and Technology
Volume 19, Issue 1, pages e10–e19, February 2013
How to Cite
Coleman, A. J., Richardson, T. J., Orchard, G., Uddin, A., Choi, M. J. and Lacy, K. E. (2013), Histological correlates of optical coherence tomography in non-melanoma skin cancer. Skin Research and Technology, 19: e10–e19. doi: 10.1111/j.1600-0846.2012.00626.x
- Issue online: 7 JAN 2013
- Version of Record online: 28 JUN 2012
- Manuscript Accepted: 26 APR 2012
- optical coherence tomography;
- non-melanoma skin cancer
Non-melanoma skin cancer (NMSC) is rarely fatal but is now the most common malignancy occurring in white populations, accounting for 70% of the cost of managing skin cancer. Optical coherence tomography (OCT) has the potential to improve diagnostic accuracy and help delineate pre-surgical margins in NMSC. Its widespread clinical acceptance awaits the accumulation of evidence from studies of direct histological comparisons.
In this study, seventy-eight subjects presenting with skin lesions, including 28 NMSCs, were imaged using the VivoSight® OCT scanner and a biopsy taken. Haemotoxylin and eosin stained histology sections were compared with the OCT images.
The depth of superficial basal cell carcinoma (BCC) lesions (<1 mm) can be measured accurately using OCT. A low-strength OCT signal at the periphery of the cell nests seen in superficial and nodular BCC is identified as corresponding to cellular palisading. A weak inverse linear correlation (r2 = 0.3) is found between the optical attenuation coefficient measured on OCT and the nuclear-cytoplasmic ratio (N/C) of cells determined from histology.
OCT has clinical value in providing accurate dimensional measurement of superficial BCC and in identifying the presence of peripheral palisading in nodular BCC.