Article first published online: 22 JUN 2004
Volume 5, Issue 8, pages 571–576, August 2004
How to Cite
Hayes, M. J., Rescher, U., Gerke, V. and Moss, S. E. (2004), Annexin–Actin Interactions. Traffic, 5: 571–576. doi: 10.1111/j.1600-0854.2004.00210.x
- Issue published online: 22 JUN 2004
- Article first published online: 22 JUN 2004
- Received 18 May 2004, revised and accepted for publication 26 May 2004
The actin cytoskeleton is a malleable framework of polymerised actin monomers that may be rapidly restructured to enable diverse cellular activities such as motility, endocytosis and cytokinesis. The regulation of actin dynamics involves the coordinated activity of numerous proteins, among which members of the annexin family of Ca2+- and phospholipid-binding proteins play an important role. Although the roles of annexins in actin dynamics are not understood at a mechanistic level, annexins have the requisite properties to integrate Ca2+-signaling with actin dynamics at membrane contact sites. In this review we discuss the current state of knowledge on this topic, and consider how and where annexins may fit into the complex molecular machinery that regulates the actin cytoskeleton.