• 1
    Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA 2002;99: 1689916903.
  • 2
    Strausberg RL, Feingold EA, Klausner RD, Collins FS. The mammalian gene collection. Science 1999;286: 455457.
  • 3
    Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y et al. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 2002;420: 563573.
  • 4
    Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res 2004;14: 21212127.
  • 5
    Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S et al. The transcriptional landscape of the mammalian genome. Science 2005;309: 15591563.
  • 6
    Baross A, Butterfield YS, Coughlin SM, Zeng T, Griffith M, Griffith OL, Petrescu AS, Smailus DE, Khattra J, Mcdonald HL, Mckay SJ, Moksa M, Holt RA, Marra MA. Systematic recovery and analysis of full-ORF human cDNA clones. Genome Res 2004;14: 20832092.
  • 7
    Stow JL, Teasdale RD. Expression and localization of proteins in mammalian cells. In: Quackenbush J, editor. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. John Wiley & Sons. 2005.
  • 8
    Dreger M. Proteome analysis at the level of subcellular structures. Eur J Biochem 2003;270: 589599.
  • 9
    Burns N, Grimwade B, Ross-Macdonald PB, Choi EY, Finberg K, Roeder GS, Snyder M. Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae. Genes Dev 1994;8: 10871105.
  • 10
    Sawin KE, Nurse P. Identification of fission yeast nuclear markers using random polypeptide fusions with green fluorescent protein. Proc Natl Acad Sci USA 1996;93: 1514615151.
  • 11
    Cutler SR, Ehrhardt DW, Griffitts JS, Somerville CR, Random GFP. cDNA fusions enable visualization of subcellular structures in cells of Arabidopsis at a high frequency. Proc Natl Acad Sci USA 2000; 97: 37183723.
  • 12
    Escobar NM, Haupt S, Thow G, Boevink P, Chapman S, Oparka K. High-throughput viral expression of cDNA-green fluorescent protein fusions reveals novel subcellular addresses and identifies unique proteins that interact with plasmodesmata. Plant Cell 2003;15: 15071523.
  • 13
    Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep 2000;1: 287292.
  • 14
    Matlack KE, Mothes W, Rapoport TA. Protein translocation: tunnel vision. Cell 1998;92: 381390.
  • 15
    Yuan Z, Davis MJ, Zhang F, Teasdale RD. Computational differentiation of N-terminal signal peptides and transmembrane helices. Biochem Biophys Res Commun 2003;312: 12781283.
  • 16
    Mulder NJ, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Biswas M, Bradley P, Bork P, Bucher P, Copley R, Courcelle E, Durbin R, Falquet L, Fleischmann W et al. InterPro: an integrated documentation resource for protein families, domains and functional sites. Brief Bioinform 2002;3: 225235.
  • 17
    Eppig JT, Bult CJ, Kadin JA, Richardson JE, Blake JA, Anagnostopoulos A, Baldarelli RM, Baya M, Beal JS, Bello SM, Boddy WJ, Bradt DW, Burkart DL, Butler NE, Campbell J et al. The Mouse Genome Database (MGD): from genes to mice – a community resource for mouse biology. Nucleic Acids Res 2005;33: D471D475.
  • 18
    Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000;25: 2529.
  • 19
    Beissbarth T, Speed TP. GOstat: find statistically overrepresented gene ontologies within a group of genes. Bioinformatics 2004;20: 14641465.
  • 20
    Hennet T. The galactosyltransferase family. Cell Mol Life Sci 2002; 59: 10811095.
  • 21
    Gene Ontology Consortium. Creating the gene ontology resource: design and implementation. Genome Res 2001;11: 14251433.
  • 22
    Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, Eilbeck K, Lewis S, Marshall B, Mungall C, Richter J, Rubin GM, Blake JA, Bult C, Dolan M et al. The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res 2004;32: D258D261.
  • 23
    Cunnea PM, Miranda-Vizuete A, Bertoli G, Simmen T, Damdimopoulos AE, Hermann S, Leinonen S, Huikko MP, Gustafsson JA, Sitia R, Spyrou G. ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. J Biol Chem 2003;278: 10591066.
  • 24
    Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH. Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs. J Cell Biol 1998;141: 14891502.
  • 25
    Pikkarainen T, Brannstrom A, Tryggvason K. Expression of macrophage MARCO receptor induces formation of dendritic plasma membrane processes. J Biol Chem 1999;274: 1097510982.
  • 26
    Rodriguez MJ, Saura J, Billett EE, Finch CC, Mahy N. Cellular localization of monoamine oxidase A and B in human tissues outside of the central nervous system. Cell Tissue Res 2001;304: 215220.
  • 27
    Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem 1998;273: 1503015034.
  • 28
    Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA. A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins. Curr Biol 1999;9: 385388.
  • 29
    Smit A, Hubley R, Green P. RepeatMasker Open-3.0 1996 (available from
  • 30
    Grimmond SM, Miranda KC, Yuan Z, Davis MJ, Hume DA, Yagi K, Tominaga N, Bono H, Hayashizaki Y, Okazaki Y, Teasdale RD. The mouse secretome: functional classification of the proteins secreted into the extracellular environment. Genome Res 2003;13: 13501359.
  • 31
    Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003;4: P3.
  • 32
    Kim KU, Kwon OJ, Jue DM. Pro-tumour necrosis factor cleavage enzyme in macrophage membrane/particulate. Immunology 1993;80: 134139.
  • 33
    Teasdale RD, Jackson MR. Signal-mediated sorting of membrane proteins between the endoplasmic reticulum and the Golgi apparatus. Annu Rev Cell Dev Biol 1996;12: 2754.
  • 34
    Shen J, Prywes R. ER stress signaling by regulated proteolysis of ATF6. Methods 2005;35: 382389.
  • 35
    Johnston JA, Ward CL, Kopito RR. Aggresomes: a cellular response to misfolded proteins. J Cell Biol 1998;143: 18831898.
  • 36
    Belpaire F, Laduron P. Tissue fractionation and catecholamines. I. Latency and activation properties of dopamine-beta-hydroxylase in adrenal medulla. Biochem Pharmacol 1968;17: 411421.
  • 37
    Potter LT, Axelrod J. Subcellular localization of catecholamines in tissues of the rat. J Pharmacol Exp Ther 1963;142: 291298.
  • 38
    Hartman BK, Udenfriend S. The application of immunological techniques to the study of enzymes regulating catecholamine synthesis and degradation. Pharmacol Rev 1972;24: 311330.
  • 39
    Houhou L, Lamouroux A, Biguet NF, Mallet J. Expression of human dopamine beta-hydroxylase in mammalian cells infected by recombinant vaccinia virus. Mechanisms for membrane attachment. J Biol Chem 1995;270: 1260112606.
  • 40
    Milland J, Russell SM, Dodson HC, Mckenzie IF, Sandrin MS. The cytoplasmic tail of alpha 1,3-galactosyltransferase inhibits Golgi localization of the full-length enzyme. J Biol Chem 2002;277: 1037410378.
  • 41
    Yang W, Pepperkok R, Bender P, Kreis TE, Storrie B. Modification of the cytoplasmic domain affects the subcellular localization of Golgi glycosyl-transferases. Eur J Cell Biol 1996;71: 5361.
  • 42
    Verkoczy LK, Guinn B, Berinstein NL. Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells. J Biol Chem 2000;275: 2096720979.
  • 43
    Kung SK, Su RC, Shannon J, Miller RG. The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells. J Immunol 1999;162: 58765887.
  • 44
    Brennan J, Mager D, Jefferies W, Takei F. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. J Exp Med 1994;180: 22872295.
  • 45
    Wong S, Freeman JD, Kelleher C, Mager D, Takei F. Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains. J Immunol 1991;147: 14171423.
  • 46
    Ackermann U, Geering K. Mutual dependence of Na,K-ATPase alpha- and beta-subunits for correct posttranslational processing and intracellular transport. FEBS Lett 1990;269: 105108.
  • 47
    Bonifacino JS, Suzuki CK, Lippincott-Schwartz J, Weissman AM, Klausner RD. Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly. J Cell Biol 1989;109: 7383.
  • 48
    Abbott GW, Butler MH, Bendahhou S, Dalakas MC, Ptacek LJ, Goldstein SA. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell 2001; 104: 217231.
  • 49
    Fink JL, Aturaliya R, Davis MJ, Hanson K, Teasdale MS, Teasdale RD. LOCATE: a mouse protein subcellular localization database. Nucleic Acids Res 2006;34: D213D217.
  • 50
    Su AI, Cooke MP, Ching KA, Hakak Y, Walker JR, Wiltshire T, Orth AP, Vega RG, Sapinoso LM, Moqrich A, Patapoutian A, Hampton GM, Schultz PG, Hogenesch JB. Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci USA 2002;99: 44654470.
  • 51
    Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y. Protein – protein interaction panel using mouse full-length cDNAs. Genome Res 2001;11: 17581765.
  • 52
    Noy GP, Weissbach A. HeLa cell DNA polymerases: the effect of cycloheximide in vivo and detection of a new form of DNA polymerase alpha. Biochim Biophys Acta 1977;477: 7083.