Clathrin-Coated Pits: Vive La Différence?

Authors

  • Alexandre Benmerah,

    Corresponding author
    1. Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France
    2. INSERM, U567, 75014 Paris, France
      Alexandre Benmerah, benmerah@cochin.inserm.fr or Christophe Lamaze, christophe.lamaze@curie.fr
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  • Christophe Lamaze

    Corresponding author
    1. Laboratoire Trafic et Signalisation, Institut Curie, Centre de Recherche, Paris, F-75248 France
    2. CNRS, UMR144, Paris, F-75248 France
      Alexandre Benmerah, benmerah@cochin.inserm.fr or Christophe Lamaze, christophe.lamaze@curie.fr
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Alexandre Benmerah, benmerah@cochin.inserm.fr or Christophe Lamaze, christophe.lamaze@curie.fr

Abstract

Because of the discovery of coated pits and vesicles more than 40 years ago and the identification of clathrin as a major component of the coat, it has been assumed that clathrin-coated pits (CCPs) are responsible for the uptake of most plasma membrane receptors undergoing internalization. The recent molecular characterization of clathrin-independent routes of endocytosis confirms that several alternative endocytic pathways operate at the plasma membrane of mammalian cells. This heterogeneous view of endocytosis has been expanded still further by recent studies, suggesting that different subpopulations of CCPs responsible for the internalization of specific sets of cargo may coexist. In the present review, we have discussed the experimental evidence in favor or against the existence of distinct parallel clathrin-dependent pathways at the plasma membrane.

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