• 1
    Borgese N, Colombo S, Pedrazzini E. The tale of tail-anchored proteins: coming from the cytosol and looking for a membrane. J Cell Biol 2003;161:10131019.
  • 2
    Wattenberg B, Lithgow T. Targeting of C-terminal (tail)-anchored proteins: understanding how cytoplasmic activities are anchored to intracellular membranes. Traffic 2001;2:6671.
  • 3
    Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 1993;53:47014714.
  • 4
    Lithgow T, van Driel R, Bertram JF, Strasser A. The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane. Cell Growth Differ 1994;5:411417.
  • 5
    Lederer F, Ghrir R, Guiard B, Cortial S, Ito A. Two homologous cytochromes b5 in a single cell. Eur J Biochem 1983;132:95102.
  • 6
    Isenmann S, Khew-Goodall Y, Gamble J, Vadas M, Wattenberg BW. A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. Mol Biol Cell 1998;9:16491660.
  • 7
    Stefanovic S, Hegde RS. Identification of a targeting factor for posttranslational membrane protein insertion into the ER. Cell 2007;128:11471159.
  • 8
    Ahting U, Waizenegger T, Neupert W, Rapaport D. Signal-anchored proteins follow a unique insertion pathway into the outer membrane of mitochondria. J Biol Chem 2005;280:4853.
  • 9
    Brambillasca S, Yabal M, Makarow M, Borgese N. Unassisted translocation of large polypeptide domains across phospholipid bilayers. J Cell Biol 2006;175:767777.
  • 10
    Bellot G, Cartron PF, Er E, Oliver L, Juin P, Armstrong LC, Bornstein P, Mihara K, Manon S, Vallette FM. TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. Cell Death Differ 2006;14:785794.
  • 11
    Burri L, Varlamov O, Doege CA, Hofmann K, Beilharz T, Rothman JE, Sollner TH, Lithgow T. A SNARE required for retrograde transport to the endoplasmic reticulum. Proc Natl Acad Sci U S A 2003;100:98739877.
  • 12
    Beilharz T, Egan B, Silver PA, Hofmann K, Lithgow T. Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae. J Biol Chem 2003;278:82198223.
  • 13
    Bendtsen JD, Nielsen H, von Heijne G, Brunak S. Improved prediction of signal peptides: SignalP 3.0. J Mol Biol 2004;340:783795.
  • 14
    Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol Biol Cell 1998;9:14371448.
  • 15
    Claros MG, Vincens P. Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur J Biochem 1996;241:779786.
  • 16
    Allen R, Egan B, Gabriel K, Beilharz T, Lithgow T. A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase. FEBS Lett 2002;514:347350.
  • 17
    Johnston AJ, Hoogenraad J, Dougan DA, Truscott KN, Yano M, Mori M, Hoogenraad NJ, Ryan MT. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. J Biol Chem 2002;277:4219742204.
  • 18
    Armstrong LC, Komiya T, Bergman BE, Mihara K, Bornstein P. Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion. J Biol Chem 1997;272:65106518.
  • 19
    Alonso MA, Weissman SM. cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation. Proc Natl Acad Sci U S A 1987;84:19972001.
  • 20
    Horie C, Suzuki H, Sakaguchi M, Mihara K. Characterization of signal that directs C-tail-anchored proteins to mammalian mitochondrial outer membrane. Mol Biol Cell 2002;13:16151625.
  • 21
    Kuroda R, Ikenoue T, Honsho M, Tsujimoto S, Mitoma Jy, Ito A. Charged amino acids at the carboxyl-terminal portions determine the intracellular locations of two isoforms of cytochrome b5. J Biol Chem 1998;273:3109731102.
  • 22
    Cartron PF, Priault M, Oliver L, Meflah K, Manon S, Vallette FM. The N-terminal end of Bax contains a mitochondrial-targeting signal. J Biol Chem 2003;278:1163311641.
  • 23
    Ito K, Komazaki S, Sasamoto K, Yoshida M, Nishi M, Kitamura K, Takeshima H. Deficiency of triad junction and contraction in mutant skeletal muscle lacking junctophilin type 1. J Cell Biol 2001;154:10591067.
  • 24
    Tsai FM, Shyu RY, Jiang SY. RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. Cell Signal 2007;19:989999.
  • 25
    Lewis JL, Dong M, Earles CA, Chapman ER. The transmembrane domain of syntaxin 1A is critical for cytoplasmic domain protein-protein interactions. J Biol Chem 2001;276:1545815465.
  • 26
    Quinones B, Riento K, Olkkonen VM, Hardy S, Bennett MK. Syntaxin 2 splice variants exhibit differential expression patterns, biochemical properties and subcellular localizations. J Cell Sci 1999;112:42914304.
  • 27
    Watson RT, Pessin JE. Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5. Am J Physiol Cell Physiol 2001;281:C215C223.
  • 28
    Kyte J, Doolittle RF. A simple method for displaying the hydropathic character of a protein. J Mol Biol 1982;157:105132.