Substantial uncertainties have emerged in Arctic climate change projections by the fourth Intergovernmental Panel on Climate Change assessment report climate models. In particular, the models as a group considerably underestimate the recent accelerating sea ice reduction. To better understand the uncertainties, we evaluated sensitivities of summer sea ice coverage to global warming forcing in models and observations. The result suggests that the uncertainties result from the large range of sensitivities involved in the computation of sea ice mass balance by the climate models, specifically with the changes in sea ice area (SIA) ranging from 0.09 × 106 to −1.23 × 106 km2 in response to 1.0 K increase of air temperature. The sensitivities also vary largely across ensemble members in the same model, indicating impacts of initial condition on evolution of feedback strength with model integrations. Through observationally constraining, the selected model runs by the sensitivity analysis well captured the observed changes in SIA and surface air temperatures and greatly reduced their future projection uncertainties to a certain range from the currently announced one. The projected ice-free summer Arctic Ocean may occur as early as in the late 2030s using a criterion of 80% SIA loss and the Arctic regional mean surface air temperature will be likely increased by 8.5 ± 2.5°C in winter and 3.7 ± 0.9°C in summer by the end of this century.