Immunology of Spontaneous Abortion and Hydatidiform Mole

Authors

  • SHOSHICHI TAKEUCHI MD

    Chairman, Corresponding author
    1. Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan
      Dept. of Obstetrics and Gynecology, Niigata University School of Medicine, 1–757 Asahimachi-Dori, Niigata, Japan.
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  • This study was supported by grants from the Ministry of Education and the Ministry of Public Health and Welfare, Japan.

Dept. of Obstetrics and Gynecology, Niigata University School of Medicine, 1–757 Asahimachi-Dori, Niigata, Japan.

Abstract

ABSTRACT: Our study of the sequence of morphological events leading to the formation of hydatidiform mole (HM) led us to this study. Our object in this paper is to present evidence supporting our 1971 hypothesis with results obtained by various immunological methods in our laboratory, and to propose the importance of an immunoregulatory mechanism by blocking antibody (BA).

Our hypothesis is that the conceptus, after the early demise of the embryo, may be dropped out in most cases as spontaneous abortion (SpA), and the trophoblast in the remaining cases continues to grow, developing into HM by an “immune selection” mechanism.

Our conclusion is that the trophoblast will be damaged by immune cytotoxic mechanism through a decrease of BA in SpA, and continue to grow in HM through continuous production of BA after the demise of the embryo.

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