Supported in part by grants from the Andrew Mellon Foundation and NIH Grant HD-06274.
The Interfering Effect of Human IgG Antisperm Antibodies on Human Sperm Penetration of Zona-Free Hamster Eggs*
Article first published online: 9 MAY 2013
American Journal of Reproductive Immunology
Volume 1, Issue 1, pages 40–43, May 1980
How to Cite
HAAS, G. G., SOKOLOSKI, J. E. and WOLF, D. P. (1980), The Interfering Effect of Human IgG Antisperm Antibodies on Human Sperm Penetration of Zona-Free Hamster Eggs. American Journal of Reproductive Immunology, 1: 40–43. doi: 10.1111/j.1600-0897.1980.tb00009.x
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Radioimmunoassay of antisperm antibodies;
- human sperm/hamster egg penetration test
ABSTRACT: A liquid-phase radioimmunoassay was used to quantitate sperm-associated IgG in a population of patients with unexplained infertility. Plasma IgG antisperm antibody activity was identified in a subpopulation of these patients. Using the human sperm/hamster egg assay, a unique functional test of human sperm penetrating capacity, we identified a subset of these positive patients whose plasma significantly and reproducibly inhibited penetration. This study implies that antigen-antibody reactions may prevent sperm responses that are critical to sperm-egg fusion.